The End of Alzheimer’s notes

by | Aug 25, 2023 | Articles, Conditions, Neurologic

My notes from reading “The End of Alzheimer’s” by Dr Bredesen

– Most have ApoE 3/3 = 9% AD risk

– 25% have a single ApoE4 = 30% risk

– 2% have two ApoE4 = 50% risk

– 2/3 of AD patients are ApoE4 positive


– ApoE4 positive = inflammatory state – devoted to defense

– ApoE4 negative = metabolic state – devoted to metabolism, regeneration, longevity

AD types

Type 1 – Inflammatory / hot

Type 2 – Atrophic / cold

Type 1.5 – Glycotoxic / sweet

Type 3 – Toxic / vile

Type 4 – Vascular / pale

Type 5 – Traumatic / dazed

Key steps – removal, resilience, rebuilding

  1. Address insulin resistance
  2. Get into ketosis
  3. Optimize nutrient, hormone and trophic support
  4. Resolve and prevent inflammation
  5. Treat chronic pathogens
  6. Identify and remove toxins
  7. Optimize sleep and r/o sleep apnea


The Toxin Solution, by Joseph Pizzorno

Brain Maker, by Perlmutter

Ketone meters – precision xtra, keto-mojo, keto guru

iHeart – SphygmoCor – PWV measuring

The ultra premium extra virgin olive oil site

Ketoflex Diet

Ideal ketones 1-4 mmol/L, fasting insulin <5, A1C <5.3, homocysteine <7, TG/HDL <2:1

Eliminate simple carbs – sugar, candy, cookies, muffins, cakes, breads, pastas, crackers, white potatoes, grains, soft drinks, fruit juices, alcohol, processed foods, HFCS

For those with NCGS eliminate grains – wheat, rice, corn, oats, millet, amaranth, bulgur, buckwheat, quinoa, dairy

Chronometer for tracking macronutrient ratios

ReCODE labs


Vitamins B6, B12 and folate, C, D, E

Rbc magnesium, Copper, zinc, selenium (these might get from “micronutrients, mineral/element panel – Quest)

CoEnzyme Q, Glutathione

CoQ, A, C, E (micronutrients, antioxidant panel – quest)

CMP, Fasting glucose, Fasting insulin, HbA1c

Advanced lipid panel, (Cardio IQ – Quest)

Homocysteine, hs-CRP

(Omega check – Quest)

Omega-6 to omega-3 ratio

Omega-3 index

Arachadonic acid to EPA ratio


Leaky gut – cyrex array 2

Leady blood brain barrier – cyrex array 20

Gluten and celiac antibodies


E, P and T


DHEA, pregnenolone

Thyroid and abs


Heavy metals

Mercury tri test

Organic toxins



Biotoxin panel – C4a, TGF-beta 1, MMP-9, MSH (labcorp)



CD57 (NK Cells, LGLS (CD57), Blood – Quest)


Tick borne disease, HSV

Noc Ox

Oral pathogens





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