My notes from reading “The End of Alzheimer’s” by Dr Bredesen
– Most have ApoE 3/3 = 9% AD risk
– 25% have a single ApoE4 = 30% risk
– 2% have two ApoE4 = 50% risk
– 2/3 of AD patients are ApoE4 positive
– ApoE4 positive = inflammatory state – devoted to defense
– ApoE4 negative = metabolic state – devoted to metabolism, regeneration, longevity
AD types
Type 1 – Inflammatory / hot
Type 2 – Atrophic / cold
Type 1.5 – Glycotoxic / sweet
Type 3 – Toxic / vile
Type 4 – Vascular / pale
Type 5 – Traumatic / dazed
Key steps – removal, resilience, rebuilding
- Address insulin resistance
- Get into ketosis
- Optimize nutrient, hormone and trophic support
- Resolve and prevent inflammation
- Treat chronic pathogens
- Identify and remove toxins
- Optimize sleep and r/o sleep apnea
Misc
The Toxin Solution, by Joseph Pizzorno
Brain Maker, by Perlmutter
Ketone meters – precision xtra, keto-mojo, keto guru
iHeart – SphygmoCor – PWV measuring
The ultra premium extra virgin olive oil site
Ketoflex Diet
Ideal ketones 1-4 mmol/L, fasting insulin <5, A1C <5.3, homocysteine <7, TG/HDL <2:1
Eliminate simple carbs – sugar, candy, cookies, muffins, cakes, breads, pastas, crackers, white potatoes, grains, soft drinks, fruit juices, alcohol, processed foods, HFCS
For those with NCGS eliminate grains – wheat, rice, corn, oats, millet, amaranth, bulgur, buckwheat, quinoa, dairy
Chronometer for tracking macronutrient ratios
ReCODE labs
(Labcorp)
Vitamins B6, B12 and folate, C, D, E
Rbc magnesium, Copper, zinc, selenium (these might get from “micronutrients, mineral/element panel – Quest)
CoEnzyme Q, Glutathione
CoQ, A, C, E (micronutrients, antioxidant panel – quest)
CMP, Fasting glucose, Fasting insulin, HbA1c
Advanced lipid panel, (Cardio IQ – Quest)
Homocysteine, hs-CRP
(Omega check – Quest)
Omega-6 to omega-3 ratio
Omega-3 index
Arachadonic acid to EPA ratio
Leaky gut – cyrex array 2
Leady blood brain barrier – cyrex array 20
Gluten and celiac antibodies
Hormones
E, P and T
Cortisol
DHEA, pregnenolone
Thyroid and abs
Toxins
Heavy metals
Mercury tri test
Organic toxins
Glyphosate
Biotoxin panel – C4a, TGF-beta 1, MMP-9, MSH (labcorp)
VCS
ERMI, HERSTMI2
CD57 (NK Cells, LGLS (CD57), Blood – Quest)
MARCoNS
Tick borne disease, HSV
Noc Ox
Oral pathogens
CDSA
Immunknow
