CLASS I CYTOXIC AGENTS
Artecin, Artesunate, Super Artemisinin (sweet wormwood)
Artecin, Artesunate, and Super Artemisinin are derived from the sweet wormwood plant (Artemisia annua), and have demonstrated potential anticancer properties through several mechanisms:
Selective Toxicity: Wormood contains an endoperoxide moiety that reacts with iron to produce reactive oxygen species (ROS). Cancer cells typically exhibit elevated iron uptake to support their rapid growth, making them more susceptible to artemisinin-induced ROS, which can damage cellular components and lead to cell death. science.org
Induction of Apoptosis: Studies have shown that wormwood can trigger apoptosis (programmed cell death) in various cancer cell lines. For instance, research indicates that artemisinin induces apoptosis in human leukemia cells by generating ROS and disrupting mitochondrial function. pubmed.ncbi.nlm.nih.gov
Inhibition of Cell Proliferation: Wormwood has been observed to inhibit the proliferation of cancer cells by interfering with cell cycle progression. In breast cancer cells, artemisinin treatment resulted in cell cycle arrest and reduced expression of proteins essential for cell division. researchmatters.in
Anti-Angiogenic Effects: Artemisinin and its derivatives have demonstrated the ability to inhibit angiogenesis—the formation of new blood vessels—which is crucial for tumor growth and metastasis. By suppressing angiogenesis, artemisinin can potentially limit tumor expansion. pmc.ncbi.nlm.nih.gov
Amygdalin (B17)
Amygdalin, a naturally occurring compound found in the seeds of fruits like apricots, bitter almonds, and peaches, has been investigated for its potential anticancer properties. The compound is metabolized in the body to release cyanide, a toxic substance that has been hypothesized to selectively target and kill cancer cells.
Mechanism of Action: Amygdalin is broken down in the body into glucose, benzaldehyde, and hydrogen cyanide. Theoretically, the cyanide released could target cancer cells, which are believed to have higher levels of beta-glucosidase, an enzyme that activates amygdalin. This selective activation was thought to spare normal cells, which have lower levels of this enzyme.
Agaricus Blazei Murill
Agaricus blazei Murill (AbM), commonly known as the Himematsutake mushroom, has been studied for its potential anticancer properties. Research suggests that AbM may combat cancer through several mechanisms:
Immunomodulation: AbM is rich in polysaccharides, particularly β-glucans, which can enhance the immune system. Studies have shown that AbM stimulates innate immune cells such as monocytes, natural killer (NK) cells, and dendritic cells, leading to increased Th1 responses. This shift in immune balance may improve the body’s ability to fight cancer. pmc.ncbi.nlm.nih.gov
Direct Antitumor Effects: Components of AbM, including ergosterol derivatives, have demonstrated direct antitumor activities. For instance, Agarol, an ergosterol derivative from AbM, has been shown to induce apoptosis (programmed cell death) in various cancer cell lines, such as lung adenocarcinoma (A549) and gastric cancer (MKN45) cells. This apoptosis is associated with increased reactive oxygen species (ROS) generation and decreased mitochondrial membrane potential. spandidos-publications.com
Enhancement of Chemotherapy Efficacy: AbM has been studied for its potential to enhance the effectiveness of chemotherapy. Research indicates that AbM extracts can increase the accumulation of chemotherapy drugs like doxorubicin in cancer cells, thereby enhancing their cytotoxic effects. This suggests that AbM may serve as an adjunct to conventional cancer treatments. mskcc.org
Anti-Inflammatory Effects: Chronic inflammation is a known factor in cancer development. AbM exhibits anti-inflammatory properties, which may contribute to its anticancer effects by reducing inflammation-related tumor progression. pmc.ncbi.nlm.nih.gov
Ascorbic Acid
Ascorbic acid, commonly known as vitamin C, has been studied for its potential role in cancer treatment through several mechanisms:
Pro-Oxidant Activity: At high concentrations, ascorbic acid can act as a pro-oxidant, generating hydrogen peroxide within the body. This reactive oxygen species can induce oxidative stress, leading to DNA damage and apoptosis (programmed cell death) in cancer cells. Notably, tumor cells often have elevated iron levels, which can enhance the pro-oxidant effects of ascorbic acid, selectively targeting and killing these cells. medicine.uiowa.edu
Enhancement of Chemotherapy Efficacy: Research indicates that ascorbic acid may enhance the effectiveness of certain chemotherapy drugs. In vitro studies have demonstrated that adding ascorbic acid to the medium can increase the susceptibility of cancer cells to agents like etoposide, cisplatin, and doxorubicin. Additionally, animal studies suggest that combining vitamin C with chemotherapy and radiotherapy can result in decreased tumor size and increased survival rates. pmc.ncbi.nlm.nih.gov
Selective Targeting of Cancer Cells: High-dose vitamin C has been shown to selectively target and kill cancer cells without harming normal cells. This selective toxicity is attributed to the higher levels of glucose transporters (GLUT1) on the surface of many cancer cells, which facilitate the uptake of dehydroascorbate (the oxidized form of vitamin C). Once inside the cell, dehydroascorbate is reduced back to ascorbic acid, leading to the generation of reactive oxygen species that can damage and kill the cancer cell. cancer.gov
Avemar Pulvis
Avemar Pulvis is a dietary supplement derived from fermented wheat germ extract (FWGE), developed by Hungarian chemist Máté Hidvégi in the 1990s. It has been studied for its potential anticancer properties through several mechanisms:
Immune System Modulation: Avemar Pulvis has been shown to enhance the activity of immune cells, such as natural killer (NK) cells and T cells, which are crucial in identifying and destroying cancer cells. This modulation may improve the body’s defense against tumors. pmc.ncbi.nlm.nih.gov
Inhibition of Tumor Growth and Metastasis: Studies suggest that Avemar Pulvis can inhibit the proliferation and spread of cancer cells. It may interfere with metabolic pathways in tumor cells, leading to reduced growth and potential prevention of metastasis. pmc.ncbi.nlm.nih.gov
Enhancement of Conventional Cancer Treatments: Research indicates that Avemar Pulvis may enhance the efficacy of conventional cancer therapies, including chemotherapy, radiation, and immunotherapy. It has been observed to improve the effectiveness of these treatments and reduce associated side effects. research.avemar.com
Bio D-Mulsion NuMedica D3
Bio D-Mulsion NuMedica D3 is a vitamin D3 supplement formulated to enhance absorption and assimilation, potentially offering benefits in cancer care. Vitamin D3 (cholecalciferol) plays a crucial role in maintaining bone health, supporting immune function, and regulating cell growth. Research has explored its potential in cancer treatment through several mechanisms:
Immune System Support: Vitamin D3 modulates the immune system by enhancing the activity of cancer-fighting immune cells, such as T cells and natural killer cells. This modulation may improve the body’s defense against cancer cells and help reduce chronic inflammation associated with cancer. bmsclinic.com.hk
Inhibition of Tumor Cell Proliferation: Studies suggest that vitamin D3 can inhibit the growth of tumor cells by regulating cell proliferation and differentiation. It may induce apoptosis (programmed cell death) in cancer cells and reduce angiogenesis (the formation of new blood vessels), thereby inhibiting tumor spread. bmsclinic.com.hk
Enhancement of Cancer Treatment Efficacy: Vitamin D3’s anti-inflammatory and antioxidant properties may improve tolerance to cancer treatments, such as chemotherapy and radiation. It can help reduce fatigue and other side effects caused by treatment, thereby enhancing patients’ quality of life. bmsclinic.com.hk
Dosage: 1200 iu/drop, 2 drops 3x/day (7200 iu/day)
Black Cumin
Black cumin (Nigella sativa), commonly known as black seed, has been studied for its potential anticancer properties, primarily attributed to its active compound, thymoquinone. Research suggests several mechanisms through which black cumin may exert its anticancer effects.
Induction of Apoptosis: Thymoquinone has been shown to induce programmed cell death in various cancer cell lines, including those of the lung, liver, and colon. This process helps eliminate malignant cells and inhibit tumor growth. pmc.ncbi.nlm.nih.gov
Antioxidant Activity: Black cumin exhibits antioxidant properties that can neutralize free radicals, thereby reducing oxidative stress—a factor known to contribute to cancer development. By mitigating oxidative damage, black cumin may help prevent the initiation and progression of cancer. oncotarget.com
Anti-Inflammatory Effects: Chronic inflammation is linked to cancer progression. Black cumin’s anti-inflammatory properties may help reduce inflammation within the tumor microenvironment, potentially slowing cancer growth and metastasis. traywellness.com
Inhibition of Angiogenesis: Thymoquinone has been observed to inhibit angiogenesis—the formation of new blood vessels that supply tumors with nutrients and oxygen. By disrupting this process, black cumin may limit tumor growth and metastasis. oncotarget.com
Enhancement of Chemotherapy: Studies suggest that black cumin may enhance the effectiveness of conventional chemotherapy drugs, potentially allowing for lower dosages and reduced side effects. This synergistic effect could improve overall treatment outcomes. traywellness.com
Butyric Acid
Butyric acid, a short-chain fatty acid produced during the fermentation of dietary fiber by gut microbiota, has been studied for its potential anticancer properties through several mechanisms:
Induction of Apoptosis: Butyric acid has been shown to induce apoptosis (programmed cell death) in cancer cells. For instance, in human colon cancer cells, butyric acid up-regulates the expression of Bax, a pro-apoptotic protein, via the c-Jun N-terminal kinase/activation protein-1 pathway, leading to increased cell death. gastrojournal.org
Inhibition of Tumor Growth: Butyric acid can inhibit the proliferation of cancer cells by modulating gene expression. It acts as a histone deacetylase (HDAC) inhibitor, leading to hyperacetylation of histones and activation of tumor suppressor genes. This epigenetic modification can suppress tumor growth and induce differentiation of cancer cells. pubmed.ncbi.nlm.nih.gov
Modulation of Glucose Metabolism: Butyric acid influences the glucose metabolism of colorectal cancer cells by reducing the abundance of membrane GLUT1 and cytoplasmic G6PD, which are involved in glycolysis. This suppression of glucose metabolism can impair cancer cell growth and enhance the efficacy of chemotherapy. frontiersin.org
Enhancement of Chemotherapy Efficacy: Studies suggest that butyric acid can enhance the effectiveness of chemotherapy drugs. For example, it has been shown to increase the sensitivity of colorectal cancer cells to 5-fluorouracil (5-FU), a common chemotherapy agent, by promoting apoptosis and inhibiting DNA synthesis. frontiersin.org
C-statin
C-Statin is a dietary supplement formulated to support normal angiogenesis—the process of forming new blood vessels. Angiogenesis is essential for tissue growth and repair; however, in cancer, it can facilitate tumor growth and metastasis by supplying tumors with nutrients and oxygen. C-Statin aims to regulate angiogenesis to prevent excessive blood vessel formation that tumors require.
Anti-Angiogenic: C-Statin contains proteoglycan molecules (PGMs) derived from bindweed extract. These PGMs have been demonstrated to support normal angiogenesis. In a chicken egg chorioallantoic membrane assay, PGMs inhibited new blood vessel growth in a dose-dependent manner, with 18%, 55%, and 73% inhibition at concentrations of 50, 100, and 200 micrograms, respectively. canceractive.com
By modulating angiogenesis, C-Statin may help restrict the abnormal blood vessel formation that tumors need to grow and spread. This regulation could potentially inhibit tumor development and metastasis.
Colloidal Silver – not used
While some in vitro studies have investigated the effects of colloidal silver on cancer cells, the current scientific evidence is limited and inconclusive. For example, a study published in Anticancer Research observed that colloidal silver induced dose-dependent cell death in MCF-7 breast cancer cells through apoptosis. pmc.ncbi.nlm.nih.gov
Given the absence of robust clinical evidence and the potential for adverse effects, colloidal silver is not recommended as a treatment for cancer.
Cordyceps Sinensis
Cordyceps is a type of parasitic fungus, but it is often referred to as a “mushroom”. However, unlike typical mushrooms that grow on the ground, Cordyceps species grow on insects, particularly caterpillars, and eventually kill the host. The fruiting body of Cordyceps, which is used for medicinal purposes, emerges from the insect’s body. Cordyceps has been studied for its potential anticancer properties through several mechanisms:
Induction of Apoptosis: Cordyceps and its active compound, cordycepin, have been shown to induce apoptosis (programmed cell death) in various cancer cell lines. This process involves the activation of caspases and modulation of signaling pathways, leading to the elimination of cancer cells. pmc.ncbi.nlm.nih.gov
Inhibition of Tumor Growth and Metastasis: Studies suggest that cordyceps can inhibit the proliferation and spread of cancer cells. It may interfere with metabolic pathways in tumor cells, leading to reduced growth and potential prevention of metastasis. digitalcommons.pcom.edu
Enhancement of Chemotherapy Efficacy: Research indicates that cordyceps may enhance the effectiveness of conventional chemotherapy drugs. For example, it has been shown to increase the sensitivity of cancer cells to chemotherapy agents, potentially improving treatment outcomes. mskcc.org
Modulation of Immune Response: Cordyceps has been found to enhance the activity of natural killer (NK) cells and other immune cells, which play a crucial role in identifying and destroying cancer cells. This immunomodulatory effect may contribute to its anticancer properties. digitalcommons.pcom.edu
DCA (dichloroacetate)
Dichloroacetate (DCA) is a compound that consists of consists of two chlorine atoms attached to a central carbon atom, which is also bonded to a carboxyl group. It has been investigated for its potential anticancer properties through several mechanisms:
Metabolic Reprogramming: Cancer cells often exhibit altered metabolism, favoring glycolysis over oxidative phosphorylation—a phenomenon known as the Warburg effect. DCA targets this metabolic shift by inhibiting pyruvate dehydrogenase kinase (PDK), leading to the activation of pyruvate dehydrogenase (PDH). This activation promotes the conversion of pyruvate into acetyl-CoA, enhancing mitochondrial oxidative phosphorylation and reducing lactate production. This metabolic reprogramming can induce apoptosis (programmed cell death) in cancer cells. pmc.ncbi.nlm.nih.gov
Inhibition of Tumor Growth: Studies have shown that DCA can suppress tumor growth in various cancer models. For instance, in glioblastoma models, DCA has been observed to depolarize mitochondria, leading to increased reactive oxygen species (ROS) production and subsequent tumor cell death. nature.com
Combination with Other Therapies: Research suggests that combining DCA with other compounds, such as curcumin, may enhance its anticancer effects. This combination approach could potentially lower the required DCA dosage and reduce associated toxicity while improving therapeutic outcomes. ar.iiarjournals.org
DDG (2-deoxy-D-glucose) – Unavailable in US
DDG is a glucose analog that has been studied for its potential to inhibit cancer cell metabolism. By interfering with glycolysis—the primary energy-producing pathway in many cancer cells—2-DG aims to deplete energy sources, thereby hindering tumor growth. Research indicates that 2-DG can sensitize cancer cells to various anticancer drugs, enhancing their effectiveness. pubmed.ncbi.nlm.nih.gov
Additionally, 2-DG has been explored in combination with other therapies to overcome drug resistance in cancer cells. For example, studies have shown that combining 2-DG with idarubicin can enhance its anticancer effects on idarubicin-resistant leukemia cells. spandidos-publications.com
Doxycycline
Doxycycline, a tetracycline-class antibiotic, has been investigated for its potential anticancer properties through several mechanisms:
Inhibition of Matrix Metalloproteinases (MMPs): Doxycycline exhibits inhibitory activity against MMPs, particularly MMP-2 and MMP-9, which are often elevated in human cancers. The increased expression and activity of these MMPs correlate with advanced tumor stage, increased metastasis, and prognosis. By inhibiting MMPs, doxycycline may reduce tumor progression and metastasis. en.wikipedia.org
Targeting Cancer Stem Cells (CSCs): Studies have shown that doxycycline can reduce the population of CSCs, which are believed to drive tumor growth, recurrence, and resistance to therapy. For instance, a clinical pilot study demonstrated that short-term pre-operative treatment with oral doxycycline effectively reduced CSC markers in early breast cancer patients. frontiersin.org
Induction of Apoptosis via Endoplasmic Reticulum (ER) Stress: Doxycycline has been observed to induce apoptosis in cancer cells through ER stress mechanisms. This selective induction of cell death in cancer cells suggests potential therapeutic applications. nature.com
Attenuation of Cancer-Related Inflammation: Doxycycline can reduce inflammation associated with cancer by decreasing plasma lysophosphatidate concentrations and inhibiting NF-κB activation. Since chronic inflammation is linked to cancer progression, doxycycline’s anti-inflammatory effects may contribute to its anticancer properties. molecular-cancer.biomedcentral.com
Combination Therapies: Research indicates that combining doxycycline with other agents, such as vitamin C, can enhance its effectiveness against CSCs. This combination therapy has been shown to be up to 100 times more effective in killing CSCs compared to using 2-DG alone. medicalnewstoday.com
Frankincense
Frankincense, derived from the resin of Boswellia trees, has been studied for its potential anticancer properties through several mechanisms:
Inhibition of Cancer Cell Growth: Research indicates that frankincense extracts can suppress the proliferation of various cancer cell lines, including breast and colon cancer cells. For instance, a study published in Breast Cancer Research and Treatment found that Boswellia extract significantly reduced tumor cell proliferation in breast cancer patients. hollingscancercenter.musc.edu
Induction of Apoptosis: Frankincense has been shown to induce apoptosis (programmed cell death) in cancer cells. A study in Oncotarget demonstrated that frankincense essential oil suppressed melanoma cancer by downregulating Bcl-2/Bax signaling pathways, leading to increased apoptosis. pmc.ncbi.nlm.nih.gov
Targeting Cancer Stem Cells: Frankincense may affect cancer stem-like cells, which are often resistant to conventional therapies. Research published in Cancer Reports indicated that frankincense extract has anticancer effects on breast cancer stem-like cells, suggesting its potential in targeting these resilient cell populations. pmc.ncbi.nlm.nih.gov
Anti-Inflammatory Effects: The boswellic acids in frankincense possess anti-inflammatory properties, which may contribute to reducing tumor growth and metastasis. A study in Oncology Reports found that frankincense essential oil suppressed cell viability, proliferation, migration, and invasion in human breast cancer cells, partly through anti-inflammatory mechanisms. spandidos-publications.com
IP6 (inositol hexaphosphate)
Inositol hexaphosphate (IP6), commonly known as phytic acid, is a naturally occurring compound found in plant seeds, grains, and legumes. Research has explored its potential anticancer properties through several mechanisms:
Inhibition of Tumor Growth and Metastasis: Studies have demonstrated that IP6 can inhibit the growth and spread of various cancer types, including colorectal cancer. For instance, research published in Frontiers in Nutrition indicates that IP6 reduces colorectal cancer metastasis by modulating gene expression, thereby suppressing tumor progression. frontiersin.org
Enhancement of Immune Function: IP6 has been shown to enhance the activity of natural killer (NK) cells, which play a crucial role in the body’s defense against tumors. This enhancement contributes to the body’s ability to recognize and destroy cancer cells more effectively. frontiersin.org
Induction of Apoptosis: IP6 can induce apoptosis (programmed cell death) in cancer cells, leading to the reduction of tumor size and progression. This effect has been observed in various cancer cell lines, including those of the colon and breast. pubmed.ncbi.nlm.nih.gov
Modulation of Cell Cycle and Differentiation: IP6 influences cell cycle regulation and promotes the differentiation of malignant cells, potentially reverting them to a more normal phenotype. This modulation can reduce uncontrolled cell proliferation characteristic of cancer. pubmed.ncbi.nlm.nih.gov
Enhancement of Chemotherapy Efficacy: Preliminary studies suggest that IP6, when combined with inositol, may enhance the anticancer effects of conventional chemotherapy, control cancer metastases, and improve the quality of life in cancer patients. pubmed.ncbi.nlm.nih.gov
Ivermectin
Ivermectin, traditionally used as an antiparasitic agent, has been investigated for its potential anticancer properties through several mechanisms:
Inhibition of Tumor Growth and Metastasis: Studies have shown that ivermectin can inhibit the proliferation and spread of various cancer cells. It achieves this by modulating multiple signaling pathways, including the inhibition of PAK1 kinase, which is involved in tumor progression. pmc.ncbi.nlm.nih.gov
Induction of Immunogenic Cell Death (ICD): Ivermectin has been observed to induce ICD, a form of cell death that stimulates the immune system to recognize and attack cancer cells. This process enhances the body’s natural defense mechanisms against tumors. nature.com
Enhancement of Chemotherapy Efficacy: Research indicates that ivermectin may enhance the effectiveness of certain chemotherapy drugs. For example, a study demonstrated that combining ivermectin with pembrolizumab, an anti-PD1 antibody, improved tumor control and induced protective immunity in animal models. cancer.gov
Reversal of Multidrug Resistance: Ivermectin has been identified as a substrate and inhibitor of P-glycoprotein, a protein that contributes to multidrug resistance in cancer cells. By inhibiting this pump, ivermectin may restore the sensitivity of cancer cells to chemotherapy. pmc.ncbi.nlm.nih.gov
Lycopene
Lycopene, a carotenoid predominantly found in tomatoes, watermelon, and pink grapefruit, has been studied for its potential anticancer properties through several mechanisms:
Antioxidant Activity: Lycopene acts as a potent antioxidant, quenching singlet oxygen and scavenging free radicals. This activity helps prevent oxidative DNA damage, a key factor in cancer development. pmc.ncbi.nlm.nih.gov
Inhibition of Cancer Cell Growth: Research indicates that lycopene can inhibit the proliferation of various cancer cell lines, including prostate and breast cancer cells. It has been observed to induce apoptosis (programmed cell death) in these cells, thereby reducing tumor growth. academic.oup.com
Modulation of Gene Expression: Lycopene influences the expression of genes involved in cell cycle regulation, apoptosis, and antioxidant defense mechanisms. By modulating these pathways, lycopene may contribute to the prevention and progression of cancer. pmc.ncbi.nlm.nih.gov
Enhancement of Chemopreventive Enzymes: Lycopene has been shown to induce the activity of enzymes involved in the metabolism of carcinogens, thereby enhancing the body’s ability to detoxify potential cancer-causing substances. pmc.ncbi.nlm.nih.gov
Pau D’Arco
Pau d’arco, derived from the inner bark of Tabebuia trees native to South America, has been traditionally used for various ailments, including cancer.
Induction of Apoptosis: Laboratory studies have identified compounds in pau d’arco, such as lapachol and beta-lapachone, that exhibit anticancer properties. These compounds have demonstrated the ability to inhibit cancer cell proliferation and induce apoptosis (programmed cell death) in various cancer cell lines. konstantinioncenter.org
Onkobel Pro
OnKobel-Pro® is a dietary supplement formulated by Dr. Mirko Beljanski, a French biochemist, to support healthy cell growth and inhibit the proliferation of abnormal cells. The formulation combines three plant extracts:
- Pao pereira (Geissospermum vellosii): Traditionally used in South American folk medicine, Pao pereira is believed to have antimalarial and anticancer properties. Preclinical studies suggest that its extracts may inhibit tumor growth and enhance the effects of certain chemotherapy agents. mskcc.org
- Rauwolfia vomitoria: This plant has been studied for its potential to support healthy cell function and may play a role in maintaining normal enzyme activity, which is crucial for cellular homeostasis. maisonbeljanski.com
- Golden Ginkgo (Ginkgo biloba): Known for its antioxidant properties, Ginkgo biloba may help protect cells from oxidative stress, a factor that can contribute to cancer development. maisonbeljanski.com
Inhibit Abnormal Cell Proliferation: The formulation is designed to target and reduce the growth of abnormal cells, potentially slowing tumor progression.
Oxaloacetate (Cronaxal)
Oxaloacetate, a key intermediate in cellular metabolism, has been investigated for its potential anticancer properties through several mechanisms:
Inhibition of the Warburg Effect: Cancer cells often rely on glycolysis for energy production, even in the presence of oxygen—a phenomenon known as the Warburg effect. Oxaloacetate has been shown to inhibit lactate dehydrogenase A (LDHA), an enzyme central to this metabolic shift, thereby reducing glycolytic activity and potentially slowing tumor growth. pmc.ncbi.nlm.nih.gov
Glutamine Metabolism Modulation: Tumor cells frequently utilize glutamine metabolism to support rapid proliferation. Oxaloacetate can interact with glutamine pathways, potentially disrupting the metabolic processes that cancer cells depend on for growth and survival. pmc.ncbi.nlm.nih.gov
Enhancement of Mitochondrial Function: By promoting mitochondrial biogenesis and improving mitochondrial function, oxaloacetate may enhance the energy production capacity of normal cells, potentially making them more resilient to the metabolic demands of cancer. pmc.ncbi.nlm.nih.gov
Poly-MVA
Poly-MVA is a dietary supplement formulated to support cellular energy production and overall health. It combines minerals, vitamins, and amino acids, including a patented lipoic acid-palladium complex (LAPd). sunridgemedical.com
Mitochondrial Support: Poly-MVA is designed to enhance mitochondrial function, which is crucial for energy production in cells. By improving mitochondrial activity, it may help maintain the health of normal cells and potentially inhibit the growth of cancer cells. sunridgemedical.com
Antioxidant Properties: The components of Poly-MVA, particularly the lipoic acid-palladium complex, are believed to possess antioxidant effects. This may help protect cells from oxidative stress, a factor associated with cancer development.pubmed.ncbi.nlm.nih.gov
Ribraxx
Ribraxx, known scientifically as rice bran arabinoxylan compound (RBAC), is a dietary supplement derived from rice bran and shiitake mushroom extract. It has been studied for its potential to support cancer treatment through several mechanisms:
Immunomodulatory Effects: Ribraxx has been shown to enhance the activity of natural killer (NK) cells, which play a crucial role in the body’s defense against tumors. This enhancement contributes to the body’s ability to recognize and destroy cancer cells more effectively. pmc.ncbi.nlm.nih.gov
Synergistic Effects with Chemotherapy: Research indicates that Ribraxx may work synergistically with conventional chemotherapy agents, potentially enhancing their effectiveness and reducing side effects. For example, a study found that combining Ribraxx with curcumin therapy improved clinical responses in patients with early-stage B-cell lymphoid malignancies. journals.sagepub.com
Improvement of Quality of Life: Clinical studies have reported that Ribraxx supplementation can improve the quality of life in cancer patients by reducing fatigue, enhancing appetite, and improving overall well-being. These benefits are particularly significant during and after conventional cancer treatments. cureus.com
Salicinium – not used
Salicinium is a natural plant-derived compound that has been explored for its potential in cancer treatment. It is believed to target and disrupt the metabolic processes of cancer cells, particularly those relying on anaerobic glycolysis for energy production. This selective targeting aims to inhibit the growth and proliferation of cancer cells while sparing healthy cells. cancerireland.ie
Targeting Anaerobic Metabolism: Cancer cells often depend on anaerobic glycolysis, a less efficient energy production pathway, even in the presence of oxygen—a phenomenon known as the Warburg effect. Salicinium is thought to interfere with this metabolic pathway, thereby depriving cancer cells of their primary energy source. cancerireland.ie
Immune System Modulation: Salicinium may enhance the immune system’s ability to recognize and eliminate cancer cells. By altering the metabolic environment of cancer cells, it could make them more susceptible to immune surveillance and destruction. cancerireland.ie
Using salicinium to treat cancer involves a specific 3 week IV protocol and a prolonged period of supplements during which time there are limitations for taking other cancer treating supplements. For this reason we don’t typically use salicinium in the rgcc rotation.
Theaflavin
Theaflavins, a group of polyphenolic compounds found in black tea, have been studied for their potential anticancer properties through several mechanisms:
Inhibition of Cancer Cell Proliferation: Research indicates that theaflavins can inhibit the proliferation of various cancer cell lines, including ovarian, liver, and lung cancers. For instance, a study published in Anticancer Research found that the four main theaflavin derivatives preferentially inhibited the proliferation of ovarian cancer cells. ar.iiarjournals.org
Induction of Apoptosis: Theaflavins have been shown to promote programmed cell death (apoptosis) in cancer cells. A study in Carcinogenesis demonstrated that theaflavins induce apoptosis in p53-mutated breast cancer cells by activating the Fas death receptor/caspase-8 pathway. academic.oup.com
Suppression of Tumor Growth and Metastasis: Theaflavins may suppress tumor growth and metastasis by blocking specific signaling pathways. Research published in OncoTargets and Therapy indicates that theaflavins can significantly inhibit proliferation, migration, and invasion, and induce apoptosis in hepatocellular carcinoma (HCC) cells. dovepress.com
Antioxidant Properties: Theaflavins possess antioxidant properties that can neutralize free radicals, thereby reducing oxidative stress—a factor known to contribute to cancer development. This activity helps protect cells from DNA damage and supports overall cellular health. webmd.com
Vitanox
Vitanox® by Standard Process is an antioxidant support formula that combines several herbal extracts, each contributing unique compounds believed to support overall health:
- Rosemary (Rosmarinus officinalis): Contains phenolic diterpenes such as carnosol and rosmarinic acid, known for their antioxidant properties.
- Green Tea (Camellia sinensis): Rich in polyphenols, including epigallocatechin gallate (EGCG), which are potent antioxidants.
- Turmeric (Curcuma longa): Provides diarylheptanoids like curcumin, recognized for their antioxidant and anti-inflammatory effects.
- Grape Seed (Vitis vinifera): Contains oligomeric procyanidins, which are powerful antioxidants.
CLASS III PK INHIBITORS
COMBINATIONS
Enhanced combinations: Vitamin C / doxycycline, DCA / curcumin,
Natural Substances that DO NOT work well together
- Genistein – Do not mix with Quercetin during the same month
- Vascustatin – Do not mix with Genistein during the same month
- Artecin – Do not use with Super Artemisinin during the same month
- Poly MVA – Do not mix with Lycopene on the same day
- IV – C – Do on opposite days of PolyMVA – or at least 6-8 hours after IV
- Salvestrol – Do not take with Resveratrol during the same month
- Artecin or Super Artemisinin – Do not do oral vitamin C on same days
