My notes during the presentation – second part is info from prodrome
ProdromeScan Practitioner Resource
Plasmalogens
With sufficiency, plasmalogens contribute to:
• Neurogenesis, neuroplasticity, myelination, and neurotransmission (‘fusogenic’ in regards to synapse connectivity).
• Endogenous antioxidant activity and free radical scavenging neutralizing peroxides in response to neuroinflammation and oxidative stress.
• Protection of essential cell membrane components–other phospholipids, lipoproteins, metabolites.
• Support of membrane stability and function including reverse cholesterol transport.
• Decreased dementia incidence and APOE4 allele related risk.
Plasmalogen Precursor Supplements
ProdromeNeuro (performance, stimulating, grey matter targeted)
Pertinent markers to consider are:
• Low plasmalogens–1b (12b), 3b (12d) and other DHA phospholipids, directly replenishes DHA- Ethanolamine Plasmalogens (2c, APOE4 risk rectification)
• Low dietary DHA (5d)
• High CRP (10b)
• High Triglycerides (12i)
• Suboptimal cholesterol transport, low HDL (section 13)
ProdromeGlia (focus, calming, restorative, white matter targeted)
Pertinent markers to consider are:
• Low plasmalogens–1b (12b), 3b (12d)
• Low dietary oleic acid, omega 9 (5a)
• Low sphingomyelins (8d)
• Ceramides (8e) > sphingomyelins (8d)
Serving/storage suggestions are:
• ProdromeNeuro is most commonly taken during the day and ProdromeGlia is most commonly taken during the evening/HOS, but can be taken anytime especially with white matter related issues.
• Softgels of ProdromeNeuro and ProdromeGlia may be kept at room temperature. ProdromeNeuro Oil is best kept in the refrigerator.
Ancillary supplement considerations are:
• Combining isolated supplements (i.e. PC) with food based sources for greater bioavailability when extreme depletion is present (pertinent to sections 1-5, 8, 12).
• Riboflavin for a homeostatic effect on iron levels (section 7) along with ALA, quercetin, and ProdromeGTA for potential chelation of high iron levels.
• Choline and creatine for decreasing demand on the methyltransferase/choline system (section 8) with B6/12 and folate supportive of homocysteine recycling.
• Support of mitochondrial function (section 9) with B1,2,3 along with L-carnitine, NAC, and CoQ10.
• Creatine for low creatinine levels (14a)
• Vitamin C for a homeostatic effect on uric acid (14c) with niacin for low levels and a bicarbonate source for high levels.
Document is intended for practitioner resource purposes only.