Repurposing niclosamide for the treatment of neurological disorders
“Thanks to its pleiotropic actions, in recent years, niclosamide has been repurposed for several diseases. Preclinical validation proved that niclosamide has efficacy against solid cancers, rheumatoid arthritis, and fibrotic conditions, and it is currently in phase II–III clinical trial for metastatic colorectal cancer, prostate cancer, and coronavirus disease 2019.”
Niclosamide: Beyond an antihelminthic drug
“Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of people worldwide. However recent studies have indicated that niclosamide may have broad clinical applications for the treatment of diseases other than those caused by parasites. These diseases and symptoms may include cancer, bacterial and viral infection, metabolic diseases such as Type II diabetes, NASH and NAFLD, artery constriction, endometriosis, neuropathic pain, rheumatoid arthritis, sclerodermatous graft-versus-host disease, and systemic sclerosis.”
