“Intriguingly, niclosamide, an FDA-approved drug for treating tapeworm infections with an excellent safety profile, displays broad anti-cancer activity in a variety of contexts… Inspired by the promising results from the pre-clinical studies, several clinical trials are ongoing to assess the therapeutic effect of niclosamide in cancer patients. This current review summarizes the functions, mechanism of action, and potential applications of niclosamide in cancer therapy as a magic bullet.”
Repurposing niclosamide for the treatment of neurological disorders
“Thanks to its pleiotropic actions, in recent years, niclosamide has been repurposed for several diseases. Preclinical validation proved that niclosamide has efficacy against solid cancers, rheumatoid arthritis, and fibrotic conditions, and it is currently in phase II–III clinical trial for metastatic colorectal cancer, prostate cancer, and coronavirus disease 2019.”
Niclosamide: Beyond an antihelminthic drug
