Growth Hormone Secretagogues (GHS), also referred to as growth hormone-releasing factors, are compounds that may be used to stimulate the body’s natural production of human growth hormone (HGH). These therapies are typically administered as subcutaneous injections under the supervision of a healthcare provider.
HGH plays a role in many biological processes, including metabolism, tissue repair, and cellular function. Natural levels of HGH are generally highest during youth and tend to decline with age. GHS aims to work with the body’s natural feedback systems to promote hormone signaling rather than replacing hormones directly.
Unlike direct administration of HGH – which introduces synthetic hormones into the body—GHS may support a more physiologic method by encouraging the body to produce its own growth hormone in a regulated, pulsatile fashion. Some patients and practitioners consider this approach to be more aligned with the body’s natural rhythms.
Current Status and Use
GHS compounds are not FDA-approved for general clinical use and are considered investigational. However, some licensed healthcare professionals offer GHS therapy in carefully monitored settings as part of a broader, individualized wellness or age-management plan. These peptides are often discussed in the context of emerging research and are typically compounded under physician supervision.
It is important to understand that the safety and efficacy of these therapies have not been fully established in large-scale human clinical trials for many of the uses currently being explored. Patients interested in these treatments should discuss the risks, benefits, and regulatory status with their healthcare provider.
These statements have not been evaluated by the Food and Drug Administration. Peptide therapy is not intended to diagnose, treat, cure, or prevent any disease.
Patients may purchase GHS by the vial for $180 to $600 per month, depending on the specific type. Before starting GHS, we recommend that patients measure their current level of IGF1 (marker of growth hormone levels) through a blood test.
References:
This is a good review article on one particular GHS called “Sermorelin”
Sermorelin- A better approach to management of adult-onset growth hormone insufficiency?
