DHEA, or Dehydroepiandrosterone, is produced by the adrenal gland and normally decreases with age, with levels starting to decline after the age of 30. DHEA has two types of actions in the body:
- Conversion: DHEA converts in the body into more potent male and female hormones including testosterone and estrogen
- Actions of its own: DHEA enhances the immune system and may protect the blood vessels against atherosclerosis
- Increased DHEA can be a result of emotional stress. Intake of foods high in protein or saturated fat can increase levels
- Decreased DHEA can be caused by a diet rich in sugar, sweets, and high fiber cereal (such as whole grain or bran flakes)
Signs and Symptoms of DHEA Deficiency
- Fatigue and/or depression
- Decreased immune system function
- Decreased sexual desire (men and women)
- Decreased exercise tolerance and loss of muscle tone
- Dry skin and eyes
- Reduced axillary (armpit) and pubic hair
Treatment
Requirements for Monitoring Therapy:
- Baseline blood testing of DHEA level. Concurrent testing of other hormones as appropriate
- Periodic blood testing of DHEA levels to assure adequate dosing
Medications:
DHEA may be found at compounding pharmacies and health food stores, concentrations vary widely so a knowledgeable professional should assure the dose is correct
- Oral DHEA is preferred
- Proper dosing will vary and depends on the amount of DHEA deficiency and the response to treatment
- Improvements may be seen after 3-4 months; six months of treatment is necessary to obtain the full effects of DHEA treatment
Signs and Symptoms of Too Much DHEA
- Unwanted body and/or facial hair
- Acne or oily skin
- Menstrual cycle disturbances
Risks and Benefits of Treatment
Risks:
- Replacement is contraindicated if there is active presnce of breast, uterine or prostate cancer
- Caution must be taken in the presence of preexisting liver disease
- DHEA should not be taken if there is no deficiency
- May worsen an untreated cortisol deficiency
Benefits:
- Improved energy levels
- Improved immune system function
- Decreased symptoms of other male and female hormone deficiencies ( such as testosterone)
