Chronic Inflammatory Response Syndrome (CIRS) Testing

by | Feb 2, 2021 | Articles, Chronic Infections, Conditions

Mold and other biotoxins may initiate a complex reaction in the body that sets off a series of biochemical alterations called chronic inflammatory response syndrome (CIRS).  Standard reference ranges may not reflect significant alterations in these markers.  Below is a list with more “functional” reference ranges along with result categories that are typical with CIRS.

Serum testing

Usually low values

  • MSH (35-81)
  • VIP (23-63)

Usually high values

  • MMP9 (85-332)
  • TGF beta 1 (< 2380)
  • C4a (0-2830)

High or low values

  • VGEF (31-86)

Dysregulated values, e.g. high ACTH with low/normal cortisol

  • ACTH (8-37)
  • Cortisol (std range)
  • ADH (1.3-13.3)
  • Serum osmolality (280-300)


Genetic variations that make one susceptible to mold and biotoxin illnesses are estimated to exist in about 25% of people.  These are specific to the genes that code for self recognition markers that help the immune system function properly.  The test is done through Labcorp and is called HLA A,B,C,DR1,3,4,5, DQ Intermediate Resolution.  (Test No 167096, CPT: 81370)

Specific genotypes increase susceptibility to molds, borrelia, MARCoNS, or combinations.

Nasal swab

Patients with mold or biotoxin illness often have a chronic, low grade infection in the nasal passages with a type of bacteria called Staph aureus.  This pathogen is often resistant to multiple antibiotics, thus being referred to as MARCoNS (multiple antibiotic resistant coagulase negative staphylococci).  A simple nasal swab is done to culture for this infection.  The testing is done through MicrobiologyDx.

GENIE (Genomic Expression: Inflammation Explained)

GENIE uses differential gene expression to reflect abnormalities in gene functioning in illnesses characterized by chronic fatigue.   Activation or suppression of certain genes play a role in the initiation and continuation of chronic illness.  Testing is done through ProgeneDX.

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