| Tests | Disease (% of time positive) |
| ANA | Lupus (95%) |
| Homogenous (diffuse) | Lupus, MCTD, drug induced lupus |
| Speckled | Lupus, sjorgrens, scleroderma, polymyositis, RA, MCTD |
| Nucleolar | Scleroderma, polymyositis |
| Centromere (peripheral) | Scleroderma, CREST |
| Drug induced Lupus | |
| Lupus | |
| ENA panel | |
| Anti-RNP | MCTD (95%), lupus, scleroderma |
| Anti-Sm | Lupus (30%), very specific |
| Anti-SS-A (Ro) | Sjogrens (75%), lupus, scleroderma |
| Anti-SS-B (La) | Sjogrens (60%), lupus, scleroderma |
| Anti-Scl-70 | Scleroderma (60%), very specific |
| Anti-Jo-1 | Polymyositis (30%), pulmonary fibrosis |
| Antiphospholipid Syndrome | |
| RF | RA |
| CCP antibodies | |
| PA (90%), gastritis (50%), thyroiditis (30%), etc | |
| ASO titer | Past Strep infection |
| ANCA | |
| pANCA | IBD, esp Ulcerative colitis |
| ASCA | IBD, esp Crohns |
| anti-CBir1 | esp Crohns, more aggressive |
| anti-Omp C | esp Crohns, more aggressive |
