Drug Resistance and Cancer Treatment
Multidrug Resistance Multidrug Resistance (MDR) refers to the ability of cancer cells to resist multiple chemotherapy drugs. This resistance is often caused by mutations or overexpression of genes such as ABCB1 (P-glycoprotein, also called MDR1), ABCC1 (MRP1), and ABCG2 (BCRP). These genes encode transporter proteins that pump chemotherapy drugs out of cancer cells, reducing their […]